ZNFX1 functions as an compensatory dsRNA recognition receptor to exert antiviral effectin orange-spotted grouper
收藏Figshare2025-09-25 更新2026-04-28 收录
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https://figshare.com/articles/dataset/_b_ZNFX1_b_b_f_b_b_unctions_as_an_b_b_compensatory_b_b_b_b_dsRNA_b_b_r_b_b_ecognition_b_b_r_b_b_eceptor_b_b_to_b_b_e_b_b_xert_b_b_a_b_b_ntiviral_b_b_e_b_b_ffec_b_b_t_b_b_in_orange-spotted_grouper_b_/30197434
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Many Actinopterygii fish lack the canonical dsRNA receptor RIG-I, leaving open questions about their antiviral capacity, alternative receptors, and fish-virus immune interactions. This study identifies A—a compensatory dsRNA sensor upregulated by OGNNV infection. By binding viral dsRNA, A exerts dual immunoregulation in different cells to modulate viral inflammation and inhibit replication. Mechanistically, it reduces brain cell neurotoxicity via suppressing IFN-I/pyroptosis, while activating TBK1-dependent IFN-I signaling in splenocytes. The study confirms A as a compensatory antiviral receptor in RIG-I-deficient fish, aiding NNV control strategies and illuminating innate immunity in RIG-I-lacking Actinopterygii.
创建时间：
2025-09-25
