Genome-wide significant epistatic pairs identified in the ARIC cohort and their replication in the NFBC199 cohort.*

*: genome-wide significant thresholds for interactions involving marginal SNPs were 2.1E-09 for TRI and 3.5E-09 for HDL; SNP1 (SNP2), chr1 (chr2), pos1 (pos2), gene1 (gene2) – name, chromosome, position and mapped gene of the first (second) SNP; Pint – P value of the interaction test; rep_SNP1 (rep_SNP2, rep_Pint) – the first (second, interaction P value) SNP of the best replicated pair;a: the genome-wide significant single SNP with marginal effects;b: genome-wide suggestive.