Summary of finding table of Huperzine A versus placebo for Alzheimer's disease.

Presentation of the summary of findings on Huperzine A versus placebo for Alzheimer’s disease in trials reporting the original score after treatment, including information about the review, GRADE of the quality of evidence, and summary of the statistical results information.Notes: *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group. †: Two of the three trials did not report the method of randomization and allocation concealment. ‡: One trial just mentioned "randomized" but did not report the method of randomization and blinding. §: The two trials just mentioned "randomized" but did not report the method of randomization. ¶: One trial could not allow to judge inconsistency of results, indirectness of evidence, imprecision and publication bias. CI: Confidence interval; MMSE: Mini-Mental State Examination; ADAS-Cog: Alzheimer’s Disease Assessment Scale-Cognitive Subscale; HDS: Hastgawa’s Dementia Scale; WMS: Wechsler Memory Scale; ADCS-ADL: Alzheimer’s disease Cooperative Study Activities of Daily Living Inventory; ADL: Activities of Daily Living Scale; CDR: Clinical Dementia Rating Scale.(GRADE Working Group grades of evidence: we rate study design and specific factors that can downgrade one or two levels of the quality of the evidence including limitations in study design or risk of bias, inconsistency of results, indirectness of evidence, imprecision and publication bias, and factors that can upgrade one or two levels of the quality of the evidence including large magnitude of effect, all plausible confounding would reduce the demonstrated effect or increase the effect if no effect was observed, and dose-response gradient. High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate.)