Autism risk gene KMT5B deficiency in prefrontal cortex induces synaptic dysfunction and social deficits via alterations of DNA repair and gene transcription. Autism risk gene KMT5B deficiency in prefrontal cortex induces synaptic dysfunction and social deficits via alterations of DNA repair and gene transcription

We performed RNAseq experiments to examine genome-wide transcriptional changes in PFC of shRNA-Kmt5b KD mice compared to GFP injected control mice. Overall design: mRNA via RNAseq analysis of three 6-8 week old shRNA-Kmt5b-injected KD mice (C57BL/6 x C3H) , and two 6-8 week old GFP-injected control mice (C57BL/6 x C3H) PFC tissue were compared.