Sleep Fragmentation and Obstructive Sleep Apnea in Pulmonary Arterial Hypertension: A Systematic Mendelian Randomization Study of 14 Sleep Traits

This dataset contains the supplementary materials for the manuscript titled "Sleep Fragmentation and Obstructive Sleep Apnea in Pulmonary Arterial Hypertension: A Systematic Mendelian Randomization Study of 14 Sleep Traits".
It includes:
1. Supplementary Tables (S1-S4): Complete lists of genetic instruments, full Mendelian randomization results, and colocalization analysis outputs.
2. Supplementary Figures (S1-S3): Scatter plots from reverse MR analysis and locus comparison plots for significant associations.
3. Supplementary Methods: Detailed descriptions of additional sensitivity and quality control procedures.
These materials provide the underlying data and extended analyses supporting the main findings of the study, which identified obstructive sleep apnea (OSA) and objective sleep fragmentation (measured by the number of sleep episodes, NSE) as independent causal risk factors for pulmonary arterial hypertension. The data are provided to ensure reproducibility, facilitate meta-analyses, and enable further exploration by the research community.