ATG7

This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

本基因编码一种E1样激活酶，该酶对于自噬及细胞质到液泡的运输至关重要。编码的蛋白质亦被认为能够调节在长期代谢应激下依赖p53的细胞周期途径。该蛋白与多种功能相关联，包括轴突膜运输、轴突稳态、线粒体自噬、脂肪细胞分化和造血干细胞的维持。可变剪接导致多个转录本变体的产生。[由RefSeq提供，2015年9月]