Microarray analysis of embryonic E15 mouse gonads from control male, female and Amh; Inhbb dKO males. Microarray analysis of embryonic E15 mouse gonads from control male, female and Amh; Inhbb dKO males

Fate determination and maintenance of fetal testes in most mammals occur cell autonomously as a result of the action of key transcription factors in Sertoli cell. In the mouse testis AMH and Activin B are required for the maintenance of Sertoli cell fate. In the absence of both AMH and Activin B initial testis differentiation (E12.5) occurs normally but, by embryonic day 15.5, Sertoli cells at the testis poles transdifferentiate into granulosa cells. Overall design: We compared the transcriptional profile of control testis, control ovaries and dKO (Amh-/-; Inhbb-/-) testis at embryonic day 15.5