Structural Characterization and Assessment of the Cytotoxicity of 2,3-Dihydro‑1H‑indene Derivatives and Coumarin Glucosides from the Bark of Streblus indicus

A pair of enantiomers and a pair of 2,3-dihydro-1H-indene epimers, rac-indidene A (rac-1), indidenes B and C (2, 3); four new coumarin glucosides (4–7); and four known coumarin glucosides (8–11) were isolated from the bark of Streblus indicus (Bur.) Corner. The structures of 1–11 were defined by physical data analyses, including MS, NMR, and single-crystal X-ray diffraction. The absolute configurations of the 2,3-dihydro-1H-indene derivatives were defined via experimental and calculated ECD data. rac-Indidene A and indidenes B and C showed inhibitory activity against A549 and MCF-7 tumor cells with IC50 values in the range of 2.2 ± 0.1 to 7.2 ± 0.9 μM.