Cyclic GMP-AMP synthase and interferon activation diminish MEF2C-mediated cognitive resilience

NIAID Data Ecosystem2026-05-01 收录

神经免疫互作

认知功能机制

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE226385 数据链接链接失效反馈

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This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

创建时间：

2023-04-27

Pyramidal neuron subtype diversity governs microglia states in the neocortex [MERFISH]

神经发育调控

神经免疫互作

Microglia are the resident immune cells of the brain, and have critical roles in circuit development and plasticity. During embryonic and postnatal development, microglia exist in multiple transcripti

NIAID Data Ecosystem100

Assessing the role of TPL2 in TauP301S mice. Assessing the role of TPL2 in TauP301S mice

Tau病理机制研究

神经免疫互作

ScRNAseq analysis shows •TPL2 KD (kinase dead) reduced TauP301S dependent IEG and MHCII activation states in microglia •TPL2 KD reduced peripheral immune cell infiltration in TauP301S mouse brain Over

NIAID Data Ecosystem40

Nociceptor-immune interactomes reveal insult-specific immune signatures of pain. Nociceptor-immune interactomes reveal insult-specific immune signatures of pain

神经免疫互作

炎症机制

Inflammatory pain associated with tissue injury and infection largely results from the heightened sensitivity of the peripheral terminals of nociceptor sensory neurons as a consequence of exposure to

NIAID Data Ecosystem30

Serotonin-1A receptor, a psychiatric disease risk factor, modulates offspring immunity via sex-dependent genetic nurture

神经免疫互作

母体激素效应

Serotonin-1A receptor (5HT1AR) is highly expressed in corticolimbic regions and its deficit has been associated with anxiety and depression. A similar reduction in 5HT1AR heterozygous knockout (Het) m

NIAID Data Ecosystem40

RNAseq profilings of enteric neurons with microbe stimulations

神经免疫互作

肠道微生物组-脑轴

We reported transcriptional characterization of enteric neurons with the stimulations of C.ramosum or P.magnus in Germ-free colons Germ-free mice were gavaged with vehicle, P.magnus or C.ramosum for t

NIAID Data Ecosystem40

Cyclic GMP-AMP synthase and interferon activation diminish MEF2C-mediated cognitive resilience

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