Microbiota orchestrates monocyte reprogramming of the tumor microenvironment via type I IFN-STING axis to promote anticancer immunity

This study sets out to investigate the mechanisms by which gut microbiota controls the mononuclear phagocyte compartment of the tumor microenvironment to elicit effective anti-tumor responses. This dataset contains single-cell RNA sequencing data of leukocytes from murine subcutaneous EL4 lymphomas from mice with intact or absent microbiota. EL4 tumor-infiltrating leukocytes sorted as LiveCD45+CD3- (CD3- leukocytes) or LiveCD45+CD3-CD19-NK1.1-TCRb-TCRgd-Ter119- (myeloid) from specific-pathogen-free (SPF) or germ-free (GF) mice and single-cell RNA-sequencing was performed on the 10X platform.