The TCR assigns naive T cells to a preferred lymph node

Naive T cells recirculate between the spleen and lymph nodes where they
mount immune responses when meeting dendritic cells presenting foreign
antigen. As this may happen anywhere, naive T cells ought to visit all
lymph nodes. Here, deep sequencing almost-complete TCR-repertoires led to
a comparison of different lymph nodes within and between individual mice.
We find strong evidence for a deterministic CD4/CD8 lineage choice and a
consistent spatial structure. Specifically, some T cells show a preference
for one or multiple lymph nodes, suggesting that their TCR interacts with
locally presented (self-)peptides. These findings are mirrored in
TCR-transgenic mice showing localized CD69-expression, retention, and cell
division. Thus, naïve T cells intermittently sense antigenically
dissimilar niches, which is expected to affect their homeostatic
competition.