Source data for the publication: Engineered modular microphysiological models of the human airway clearance phenomena

This data set contains the source data of the publication: Pedersoli, L., Zhang, S., Briatico-Vangosa, F., Petrini, P., Cardinaels, R., den Toonder, J.M.J. & Peneda Pacheco, D. (2021). Engineered modular microphysiological models of the human airway clearance phenomena. Biotechnol Bioeng. 118, 3898-3913, http://dx.doi.org/10.1002/bit.27866. This work demonstrates ad hoc mucus models of physiological and pathological mucus are combined with magnetic artificial cilia to model mucociliary transport in both physiological and pathological states. The modular concept adopted in this study enables the development of mucociliary clearance models with high versatility since these can be easily modified to reproduce phenomena characteristic of healthy and diseased human airways while allowing to determine the effect of each parameter and/or structure separately on the overall mucociliary transport. The data are experimentally obtained with methods described in the publication.

本数据集包含下述发表论文的源数据：Pedersoli L、Zhang S、Briatico-Vangosa F、Petrini P、Cardinaels R、den Toonder J.M.J. 与Peneda Pacheco D.（2021年）。论文题为《工程化模块化人体气道清除现象微生理模型》，发表于《Biotechnology and Bioengineering》（缩写：Biotechnol Bioeng.），卷118，页码范围3898-3913，DOI链接：http://dx.doi.org/10.1002/bit.27866。本研究构建了适配生理与病理状态的定制化黏液模型，并将其与磁性人工纤毛（magnetic artificial cilia）结合，以此模拟生理及病理状态下的黏液纤毛转运（mucociliary transport）过程。本研究所采用的模块化设计理念，使得黏液纤毛清除模型（mucociliary clearance models）具备极高通用性：可通过简便修改复现健康与病变人体气道的特征性生理病理现象，同时能够单独测定各参数及/或结构对整体黏液纤毛转运过程的影响。本数据集的实验数据均通过该论文中描述的实验方法获取。