Profiles of oral microbiota and metabolites in periodontitis and benign prostatic hyperplasia patients: a pilot study

BPH and chronic periodontitis are age-associated chronic inflammatory diseases that impose a considerable burden on healthcare systems annually. The pathogenesis of BPH remains unclear, with challenges in effective pharmacological management and a high propensity for recurrence. Therefore, clarifying the underlying mechanisms and risk factors for BPH and intervening early in the disease process may potentially delay disease onset and alleviate the associated healthcare burden. Recent research evidence suggests that periodontitis and periodontal pathogens contribute to the development and progression of BPH. The significance of our study is in elucidating the changes in the oral microbiome and metabolites in patients with BPH. By correlating these changes with clinical indicators of patients, we identified key microorganisms and metabolites that may play crucial roles in the process of BPH. This could provide a basis for further mechanistic exploration and disease prevention.