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TCR repertoire analysis of Tregs

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NIAID Data Ecosystem2026-03-12 收录
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Tregs rapidly accumulate in the omentum after tumor implantation and potently suppress anti-tumor immunity. To test whether Treg accumulation in omental tumors was driven by clonal expansion, we sorted CD25+ FoxP3(GFP)+ Tregs from the omenta and spleens of naive or tumor-bearing animals and sequenced the CDR3 region of their TCR beta chains.

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2021-07-29
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