Effect of pharmacological BCL-2 inhibition with venetoclax on T cell homeostasis
收藏NIAID Data Ecosystem2026-05-01 收录
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资源简介：
Venetoclax, a BCL-2 specific inhibitor, has been show to confer transcriptional changes in T cell populations. In order to elucidate how these changes may be occuring, we sought to investigate whether there are epigenetic alterations that may offer a potential explanation. To begin to answer this question, we conducted ATAC-sequencing on Treg cells isolated from FOXP3-IRES-GFP mice treated for 14 days with 50mg/kg of venetoclax and assessed for global accessibility changes. ATAC-seq of venetoclax treated CD4+ FOXP3+ Tregs isolated from the spleen
创建时间：
2023-09-01
