Immunomodulatory effects of hydrolyzed Debaryomyces hansenii in Atlantic salmon (Salmo salar L): From the in vitro model to a natural pathogen challenge after seawater transfer

Non-Saccharomyces yeast such as Debaryomyces hansenii or its cell wall-components are emerging candidates for novel functional aquafeeds, as they contain several microbe-associated molecular patterns (MAMPs) that can activate and modulate the host’s physiological responses and improve fish health and welfare. RNAseq results showed an upregulation in pathways associated with humoral immunity and complement activation in the liver. Considering these data, LAN6 could be a promising functional candidate for aquafeeds to achieve a more resilient salmon during fish farming. Comparative gene expression profiling analysis of RNA-seq data for head kidney, liver and distal intestine from Atlantic salmon fed 0.1% hydrolyzed Debaryomyces hansenii.