Construction of Benzothiophene or Benzothiopheno[2,3‑e]azepinedione Derivatives via Three-Component Domino or One-Pot Sequences
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An efficient three-component domino or one-pot strategy has been developed for the synthesis of medicinally important benzothiophene and benzothiopheno[2,3-e]azepinedione derivatives for the first time. Amine-promoted selective cleavage of C–S bond of thioisatin is the key step in this process. The reported methodology benefits from environmentally friendly solvent (H2O), wide substrate scope, good functional group tolerance, and high reaction yields.
创建时间：
2020-09-04
