New rare coding or splice site variants associated with hematological traits.

Chromosome and genomic coordinates are on build hg19 of the human genome. Allele frequencies and directions of effect are for allele A2. Effect sizes (BETA and SE) are in standard deviation units. Phet is the Cochran’s Q test heterogeneity P-value. We provide P-values in the UK Biobank (UKBB) without (non-conditional) and with (conditional) correction for the known blood-cell variants [1]. Detailed results of the conditional analyses are in S6 Table. Other phenotypes are hematological traits associated at P<5x10-8 in the meta-analyses. In the Comment column, we consider SNPs previously associated with blood-cell traits that are located 500 kb on either side of the reported rare variant. a, variants that are statistically dependent of known blood-cell trait variants; b, variants that are statistically independent from known blood-cell variants, but that are located at known blood-cell trait loci; c, new blood-cell trait locus.