Performance scores of prediction methods on data used by MutationTaster2 dataset.

aCADD, Combined Annotation Dependent Depletion; MT2, MutationTaster2; OPM, Overall performance measure; Sens, Sensitivity; Spec, Specificity; Acc, AccuracybVariants with C-score greater than 15 were considered as deleterious and lower than 15 were considered as neutral as suggested by the method developers.cHumVar trained PolyPhen-2. The performance of this version was better than for HumDiv trained PolyPhen-2 (data not shown).dPerformance scores are computed by using the predicted variants at 0.95 confidence level. The scores in the parentheses are for the predictor when the unreliable cases are included.Performance scores of prediction methods on data used by MutationTaster2 dataset.