A Convenient Synthesis, Antimicrobial Evaluation and Molecular Modeling of Some Novel Quinoline Derivatives

α, β-unsaturated carbonyl compounds<b>2a, b, 3</b> and <b>4</b> were synthesized by the Knoevenagel condensation between 2-substitutedquionoline-3-carboxaldehyde <b>1a</b> and/or <b>1b</b> with active methylene compounds. In addition, the synthesis of azlactone is achieved starting from <b>1a</b> and <i>N</i>-acetylglycine. Synthesis of pyridine, pyrane and pyrimidine derivatives <b>6</b>-<b>8</b> were accomplished via one-pot multicomponent reaction of <b>1b</b> with (acetyl acetone, malononitrile and ammonium acetate), (acetophenone, malononitrile and NaOH) or (acetyl acetone and urea in acidic medium). The new synthesized compounds showed good antimicrobial activities. The DFT calculations have been used to predict the electronic properties of the studied compounds.