Lymphoepithelioma-like carcinoma of the breast with thyroid cancer: the relationship with TP53 gene mutation

Breast and thyroid cancer are the most common malignancies noted in women. Patients with breast cancer exhibit a higher incidence of thyroid cancer than that noted in the general population1. The exact mechanism of multiple tumors remains elusive. In the present report, a case of a patient who had multiple tumors with gene mutation is reported. A patient with lymphoepithelioma-like carcinoma of the breast (LELC-B) and thyroid cancer is described. It was hypothesized that the short interval between the onset of these two types of malignant tumors may related to the patient's TP53 gene mutation. The co-occurrence of LELC-B and thyroid cancer may be attributed to gene mutations. To date, a specific relationship between gene mutations and multiple tumors is yet to be determined. Therefore, additional studies are required to address this topic.