2-D gel analysis profile comparing protein expression profiles between rifaximin (RX), rifamycin (MY), and untreated HEp-2 cells.

Reference spot numbering, pI, and MW are provided for polypeptide spots analyzed in samples RX, MY, and Media. The differences are calculated from spot percentages (individual spot density divided by total density of all measured spots). Polypeptide spots increased in MY and Media vs. RX by a fold increase of ≥1.7 and p values <0.05 are shown in bold. Bold indicates down-regulation in samples treated with Rifaximin vs. MY or Media. Spots decreased in MY and Media vs. RX by a fold decrease of ≤ −1.7 and p value <0.05 are in italics. Italics indicates up-regulated spots identified in samples treated with Rifaximin vs. MY or Media. Spot percentages are given to indicate relative abundance. Note that the p values are for n = 2 gels/sample. A total of 1,164 spots were analyzed.