The efficacy of Life Review Therapy combined with Memory Specificity Training (LRT-MST) targeting cancer patients in palliative Care: a Randomized Controlled Trial

The aim of this study
was to evaluate the efficacy of an intervention combining Life Review Therapy
(LRT) and Memory Specificity Training (MST) (LRT-MST) to improve ego-integrity
and despair among cancer patients in palliative care. In
this multicentre randomized controlled trial, cancer patients in palliative
care were randomized to the intervention group (LRT-MST; n=55) or waiting-list
control group (n=52). LRT-MST is a 4-session home-based psychological
intervention that aims to retrieve specific positive memories, to re-evaluate
life events and to reconstruct the story of a patient’s life, including the
diagnosis of incurable cancer. Outcome measures were ego-integrity and despair (NEIS),
psychological distress, anxiety and depression (HADS), quality of life (EORTC
QLQ-C15-PAL), and specificity of the autobiographical memory (AMT). NEIS, HADS
and EORTC QLQ-C15-PAL were assessed at baseline (T0), 1 month later (post-treatment;
T1), and at 1 month follow-up (T2). AMT was assessed at T0 and T1.

本研究旨在评估结合生命回顾疗法（Life Review Therapy，简称LRT）与记忆特异性训练（Memory Specificity Training，简称MST）（LRT-MST）的综合干预措施对于改善姑息治疗癌症患者自我完整性与绝望情绪的疗效。在该多中心随机对照试验中，姑息治疗阶段的癌症患者被随机分配至干预组（LRT-MST；n=55）或等待名单对照组（n=52）。LRT-MST是一种为期4次的家庭心理干预，旨在唤起特定的积极记忆，重新评估生命事件，并重构患者的生命故事，包括不可治愈的癌症诊断。评估指标包括自我完整性及绝望情绪（NEIS）、心理痛苦、焦虑和抑郁（HADS）、生活质量（EORTC QLQ-C15-PAL）以及自传体记忆的特异性（AMT）。NEIS、HADS和EORTC QLQ-C15-PAL分别在基线（T0）、治疗1个月后（治疗后；T1）以及1个月随访时（T2）进行评估，而AMT则在T0和T1时进行评估。