CIP: Obesity-Diabetes Familial Risk

The VIVA LA FAMILIA Study was designed to identify genetic variants influencing childhood obesity and its comorbidities in the Hispanic population. Family recruitment and phenotyping were conducted in 2000-2005 in Houston, TX. All enrolled children (n=1030) and parents gave written informed consent or assent. The protocol was approved by the Institutional Review Boards for Human Subject Research for Baylor College of Medicine and Affiliated Hospitals and for Texas Biomedical Research Institute. The VIVA LA FAMILIA study design and methodology have been described in detail (Butte NF, 2006). Each family was ascertained on an obese proband, defined as a BMI > 95th percentile, between the ages 4-19 y. The cross-sectional, longitudinal study design consisted of baseline measurements, with a one-year. GWAS was performed using the Illumina HumanOmni1 v1.0 BeadChips on 815 children from 263 Hispanic families and HumanOmni 2.5-8v1 on an additional 43 children. Exome sequencing is being performed on 822 children using NimbleGen capture, followed by Illumina DNA sequencing. Butte NF, Cai G, Cole SA, Comuzzie AG. Viva la Familia Study: genetic and environmental contributions to childhood obesity and its comorbidities in Hispanic population. Am J Clin Nutr 2006;84(3):646-54. PMID: 16960181]]>
Each family was ascertained on an overweight proband between the ages 4-19 y, using a bivariate ascertainment scheme (i.e., obese ≥ 95th percentile for BMI (2000 CDC Growth Reference) and ≥ 85th percentile for FM (CNRC body composition reference database). In addition, families were required to have three or more children between the ages of 4-19 y. Related families were also recruited to expand the relative pair types. Once identified, the obese proband and all siblings, 4 to 19 y of age, and their parents were invited to participate.]]>
The VIVA LA FAMILIA Study has been supported by NIH grants (R01 DK59264 and RO1 DK080457; U54 HG003273-10; MH59490) and USDA/ARS under Cooperative Agreement 58-6250-51000-037. Work performed at the Texas Biomedical Research Institute in San Antonio, Texas was conducted in facilities constructed with support from the Research Facilities Improvement Program of the National Center for Research Resources, NIH [C06 RR013556, C06 RR017515].]]>