Table S1 - Red-Backed Vole Brain Promotes Highly Efficient <i>In Vitro</i> Amplification of Abnormal Prion Protein from Macaque and Human Brains Infected with Variant Creutzfeldt-Jakob Disease Agent

Prion protein amino acid sequence alignment of red-backed vole (Myodes gapperi), meadow vole (Microtus pennsylvanicus), bank vole (Myodes glareolus), golden Syrian hamster (Mesocricetus auratus), cynomolgus macaque (Macaca fascicularis), and human (Homo sapiens). Amino acids at position 170, hypothesized to play a role in interspecies transmission and in vitro amplification of prion diseases, are highlighted. Red-backed voles are naturally polymorphic at residue 170, exhibiting the genotypes 170S/S, 170S/N, and 170N/N; only the 170S/S genotype is displayed in the figure for simplicity. The numbering convention follows the sequence for red-backed vole prion protein. (DOC)