KCND3

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene. [provided by RefSeq, Jul 2008]

电压门控钾离子通道（Kv通道）从功能及结构两方面来看，是电压门控离子通道中最复杂的类别。它们的功能多样性体现在调节神经递质释放、心率、胰岛素分泌、神经元兴奋性、上皮电解质运输、平滑肌收缩以及细胞体积等方面。在果蝇中，已鉴定出四个与序列相关的钾离子通道基因——shaker、shaw、shab和shal，并且每个基因均被发现具有人类同源基因。该基因编码钾离子通道、电压门控、shal相关亚家族的成员，该亚家族成员构成电压激活的A型钾离子通道，并在动作电位的复极化阶段中发挥着重要作用。该成员包括两种不同大小的同种型，这些同种型由该基因的交替剪接转录变体编码。 [提供者：RefSeq，2008年7月]