The extracellular matrix (ECM) and integrin adhesion complexes (IACs) composition in DU145 prostate cancer parental and radioresistant cells

Cell adhesion to the extracellular matrix (ECM) is a critical component of malignant transformation, cancer progression, and the development of radioresistance. This mechanism of cancer cell resistance to therapy is defined as the cell adhesion mediated radioresistance (CAM-RR). There are two groups of proteins whose alteration can lead to the emergence of CAM-RR: (i) adhesion molecules (collectively called adhesome) and (ii) ECM molecules (collectively called matrisome). In order to identify proteins that mediate radioresistance, in this study we analyzed the adhesomes and matrisomes of DU145 parental and radioresistant prostate cancer cells.