filanesib-hepatoblastoma

NIAID Data Ecosystem2026-05-02 收录

单细胞药物筛选

母细胞瘤治疗靶点

数据链接：

https://zenodo.org/record/15186871 数据链接链接失效反馈

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资源简介：

CellProfiler extracted single-cell features analysed in paper: "Nousiainen et al. (2025). Functional screening identifies kinesin spindle protein inhibitor filanesib as a potential treatment option for hepatoblastoma".

创建时间：

2025-04-10

The dependency factor RRM2 at the nexus of a copy number driven regulatory network and a target for synthetic lethal interactions with replication stress checkpoint addiction in high-risk neuroblastoma [3AP or the combination 3AP-prexasertib]

母细胞瘤治疗靶点

RRM2功能研究

Neuroblastoma is a pediatric tumor originating from the sympathetic nervous system responsible for 10-15% of all childhood cancer deaths. Half of all neuroblastoma patients present with high-risk dise

NIAID Data Ecosystem60

Single-Cell Morphological and Transcriptome Analysis Unveil Inhibitors of Polyploid Giant Breast Cancer Cells In Vitro

乳腺癌多倍体巨癌细胞

单细胞药物筛选

Considerable evidence suggests that breast cancer therapeutic resistance and relapse can be driven by polyploid giant cancer cells (PGCCs). The number of PGCCs increases with the stages of disease and

NIAID Data Ecosystem10

A multiplexed, single-cell sequencing screen identifies compounds that increase neurogenic reprogramming of mammalian Muller glia.

神经再生

单细胞药物筛选

Neurodegeneration in the retina of mammals causes permanent loss of vision, due to their lack of regeneration. Some non-mammalian vertebrates show robust regeneration, via the Muller glia (MG), and we

NIAID Data Ecosystem10

Additional file 2 of Personalized tumor combination therapy optimization using the single-cell transcriptome

肿瘤精准医疗

单细胞药物筛选

Additional file 2: Table S1. Summary of tumor single cell RNA-seq datasets. Table S2. Details of tumor single cell RNA-seq datasets and comboSC results. Table S3. Details of drugs from GDSC database u

NIAID Data Ecosystem30

Single-Cell Level Estrogen Receptor Activity Data

单细胞药物筛选

雌激素受体激动剂拮抗剂预测

This dataset contains normalized single-cell level data for 60 reference compounds analyzed with high throughput microscopy and high content analysis-based experiments that were performed using the GF

NIAID Data Ecosystem10

filanesib-hepatoblastoma

资源简介：

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