In many clinical settings, improving patient survival is of interest but a practical surrogate, such as time to disease progression, is instead used as a clinical trial's primary endpoint. A time-to-f
Surrogate outcomes are frequently used in cardiovascular disease research. A concern is that changes in surrogate markers may not reflect changes in disease outcomes....
Clinical trials are an essential aspect of the drug development process. Clinical endpoints and surrogate endpoints are two terms used in clinical trials to measure the effectiveness of a treatment. W
Progression-Free Survival (PFS) is often employed as a surrogate endpoint for Overall Survival (OS) in oncology trials to expedite evaluation processes. However, its statistical validity as a surrogat