Bioresorbable fibers for interstitial null-separation diffuse optical spectroscopy using fast temporal gating

This dataset contains the rawdata, metadata, tools and the final results for the demonstration of interstitial spectroscopy with bioresorbable fibers at null distance, using time-domain diffuse optics that disentangles absorption from scattering properties and probes the tissues up to a depth of a few cm around the fiber tips. We exploit a fast-gated single-photon avalanche diode with 55 dB of dynamic range to overcome the burst of ‘early’ photons hiding the information of absorption from deep tissues. We tested the absorption linearity—retrieving the water spectrum in the 700–950 nm range with 85% accuracy over two decades of absorption change—and verified the hypothesis of a scattering-independent absorption retrieval. Further, we were able to detect spectral changes at a distance of 1 cm from an inclusion embedded in a biological tissue.