Massa Medicata Fermentata treated spleen deficiency constipation by mediating intestinal microbiota and serum peptide

18 male Kunming mice were randomly divided into three treatment groups: Normal groups , Model groups, and Massa Medicata Fermentata intervention group. CM and CG were established a spleen deficiency constipation mouse model. After the mold is finished, the CG was infused with 0.15 g/mL Massa Medicata Fermentata water infusion at a dose of 4 g/(kg day), twice a day at 0.4 mL. An equal amount of distilled water was infused in CC and CM for 7 days. The body weight and faecal water content of the mice were monitored during the modeling. Following the intervention, 16S rRNA amplicon sequencing was used to analyze changes in the microflora in the intestinal contents