Comparison of CFRs from predictions for ASIC1a and literature.

Residues listed are those implicated in the literature as pH-sensing for ASIC1a (see text), followed by whether these amino acids are also highlighted in the three calculations (indicated by x). Open is the partially open 4fz0 structure and closed the 2qts desensitised structure. Description of the scheme that uses repacking to identify partially buried groups is given in Materials and Methods.Comparison of CFRs from predictions for ASIC1a and literature.