Mismatch repair proteins expression and tumor-infiltrating T-cells in colorectal cancer

Microsatellite instability (MSI) and tumor mutational burden (TMB) are indicators of the tumor mutational load, which can lead to immune cell recruitment. By contrast, the number of tumor-infiltrating T cells (TITs) is indicative of the host immune response to tumor cells. The present study evaluated if the expression of mismatch repair (MMR) proteins can be used as a precise tool to assess immunogenicity in the tumor microenvironment, which was performed using TIT (counting CD3+ and CD8+ cells in a tumor ) analyses and TMB tests (the total number of variants found in the DNA of cancer cells)