首页/数据集/Additional file 7 of MRE11:p.K464R mutation mediates olaparib resistance by enhancing DNA damage repair in HGSOC

Additional file 7 of MRE11:p.K464R mutation mediates olaparib resistance by enhancing DNA damage repair in HGSOC

NIAID Data Ecosystem2026-05-01 收录

数据链接：

https://figshare.com/articles/dataset/Additional_file_7_of_MRE11_p_K464R_mutation_mediates_olaparib_resistance_by_enhancing_DNA_damage_repair_in_HGSOC/24209253 数据链接链接失效反馈

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资源简介：

Supplementary Material 7

应用场景：

创建时间：

2023-09-27

DNA损伤修复

抗癌药物设计

Homologous recombination repair (HRR), a crucial approach in DNA damage repair, is an attractive target in cancer therapy and drug design. The Bloom syndrome protein (BLM) is a 3′–5′ DNA helicase that

NIAID Data Ecosystem40

Specific UV-induced mutation spectrum in the p53 gene of skin tumors from DNA-repair-deficient xeroderma pigmentosum patients.

皮肤癌突变谱

DNA损伤修复

The UV component of sunlight is the major carcinogen involved in the etiology of skin cancers. We have studied the rare, hereditary syndrome xeroderma pigmentosum (XP), which is characterized by a ver

PubMed Central1993-11-15 更新10

Genomewide nucleotide-resolution mapping of single-strand breaks and lesions by GLOE-Seq [HO endonuclease]. Genomewide nucleotide-resolution mapping of single-strand breaks and lesions by GLOE-Seq [HO endonuclease]

DNA损伤修复

基因组稳定性分析

Numerous methods are available for the mapping of DNA lesions ranging from double-strand breaks (DSBs) to incorporated ribonucleotides. We now present a technology based on the Genomewide Ligation of

NIAID Data Ecosystem10

Approximate LD50 of Aag−/− and Aag transgenic mice to various genotoxic agents.

基因毒性剂测试

DNA损伤修复

MMS, Methyl methanesulfonate; MNU, N-methyl-N-nitrosourea; AOM, Azoxymethane; MMC, Mitomycin C; CAA, Chloroacetaldehyde.*Indicates that the Aag transgene is expressed in an Aag−/− background.

Figshare2015-12-02 更新10

A new role for Rrm3 in repair of replication-born DNA breakage by sister chromatid recombination

DNA损伤修复

染色体重组

Replication forks stall at different DNA obstacles such as those originated by transcription. Fork stalling can lead to DNA double-strand breaks (DSBs) that will be preferentially repaired by homologo

Figshare2017-05-19 更新10

Additional file 7 of MRE11:p.K464R mutation mediates olaparib resistance by enhancing DNA damage repair in HGSOC

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