Mechanisms of ineffective patent foramen ovale closure using the percutaneous suture-mediated NobleStitch system.

Zannoni J, Popolo Rubbio A, Tusa MB, Corciu AI, Casenghi M, Cannone G, Barletta M, Stefanini E, Mantovani V, Gorla R, Brambilla N, Testa L, Bedogni F, De Marco F. Mechanisms of ineffective patent foramen ovale closure using the percutaneous suture-mediated NobleStitch system. EuroIntervention. 2022 May 15;18(1):68-70. doi: 10.4244/EIJ-D-21-01021. PMID: 35403602.

Introduction Percutaneous suture-mediated patent foramen ovale (PFO) closure with the “device-less” NobleStitch system (HeartStitch) has been employed in clinical practice as an effective and safe alternative to traditional device closure123. In previous studies, recurrence of a residual atrial right-to-left shunt (RLS) during follow-up was estimated at almost 20%123. In any case, specific mechanisms of failure have not been systematically described and they still remain unknown. The aim of the study was to describe the mechanisms of failure after NobleStitch from a prospective single-centre cohort.