Validation of a targeted sequencing panel for multiple myeloma

Here we provide a validated panel for targeted sequencing and analysis of myeloma and other plasma cell dyscrasias to identify the common genomic abnormalities that are diagnostic, prognostic, and clinically actionable. This panel can identify the common immunoglobulin translocations and copy number abnormalities currently detected by FISH, as well as less common translocations, MYC rearrangements, and mutations that are not currently tested for in a standard manner. We hope that adoption of a common sequencing panel will improve patient diagnostics and can be used to assist in risk stratification at diagnosis or post-treatment to guide therapeutic decision making.EGA study EGAS00001006164