Musashi 2 regulates normal hematopoiesis and accelerates leukemogenesis (LSK and LK)

ChEBI2010-07-22 更新2026-07-21 收录

造血干细胞调控

白血病分子机制

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-22774 数据链接链接失效反馈

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资源简介：

Musashi 2 regulates normal hematopoiesis and accelerates leukemogenesis (LSK and LK)

创建时间：

2010-07-22

Transcriptomic effects of forced expression of FOXO3, PRDM1⍺ and PRDM1β in pre-B ALL cell line 697 [exp1]. Transcriptomic effects of forced expression of FOXO3, PRDM1⍺ and PRDM1β in pre-B ALL cell line 697 [exp1]

白血病分子机制

肿瘤抑制基因

Lentiviral constructs expressing candidate tumoure suppressor genes were transduced into 697 cells. Of the candidates FOXO3, two isoforms of PRDM1 (⍺ and β) suppressed growth in-vitro and in-vivo. To

NIAID Data Ecosystem80

An integrated global regulatory network of hematopoietic precursor cell self-renewal and differentiation

造血干细胞调控

细胞命运决定

The mammalian blood system is a hierarchically structured tissue. Hematopoietic stem cells (HSC) reside at the top of this hierarchy and the HSC-derived progenitor cells (HPC) have capacities for both

NIAID Data Ecosystem60

Musashi 2 is a regulator of the hematopoietic stem cell compartment identified by a retroviral insertion screen and knockout mice

造血干细胞调控

基因功能研究

Musashi 2 is a regulator of the hematopoietic stem cell compartment identified by a retroviral insertion screen and knockout mice

ChEBI2011-05-21 更新20

Gene expression profile of the human T-ALL cell line JURKAT after TYK2 and STAT1 knockdown

白血病分子机制

基因靶向治疗

Targeted molecular therapy has yielded remarkable outcomes in certain cancers, but specific therapeutic targets remain elusive for many others. As a result of two independent RNA interference (RNAi) s

NIAID Data Ecosystem70

An integrated global regulatory network of hematopoietic precursor cell self-renewal and differentiation. Mus musculus

造血干细胞调控

细胞命运决定

NIAID Data Ecosystem30