Parameters used in the optimization process and their boundaries.

The parameters kUL,LL,UR,MR,LR refer to the permeabilities for the five lobes as illustrated in Fig 4A. μ, α and ν are the material properties defined in Eq 1. The airways are characterized by the stiffness C10 from Eq 2, and the coefficient λ drives the mechanical behavior of the pleura based on Eq 3.