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资源简介:
Whole-genome sequencing for determining off-target
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创建时间:
2019-10-12
相关数据集
AAV integration in human hepatocytes
Recombinant adeno-associated viral (rAAV) vectors are considered promising tools for gene therapy directed at the liver. While rAAV is thought to be an episomal vector, its single stranded DNA genome
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Macaca fascicularis Raw sequence reads. Macaca fascicularis
In order to assess a potential genotoxic effect of intracerebral lentiviral (LV)-mediated gene transfer at the molecular level, these data characterise the genomic integration profile of the LV constr
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Comparing molecular and computational approaches for detecting viral integration of AAV gene therapy constructs
Samples of cynomolgus macaque and mouse processed with three different molecular methods for insertional mutagenesis assessment
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Long-Term Vector Integration Site Analysis Following Retroviral Mediated Gene Transfer to Hematopoietic Stem Cells for the Treatment of HIV Infection
We previously reported the efficacy of nonmyeloablative allogeneic transplantation in 2 HIV positive recipients, one of whom received retrovirus transduced hematopoietic stem cells to confer resistanc
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Choice of Template Delivery Mitigates the Genotoxic Risk and Adverse Impact of Editing in Human Hematopoietic Stem Cells (RAAVIoli sequencing)
Long-range gene editing by homology-directed repair (HDR) in hematopoietic stem/progenitor cells (HSPCs) often relies on viral transduction with recombinant adeno-associated viral vector (AAV) for tem
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