Clinical isolate from the Amazon River region. Helicobacter pylori Shi470

Helicobacter pylori Shi470. Helicobacter pylori Shi470 is a clinical isolate from gastric antrum from Amerindian resident of remote Amazonian village of Shimaa, Peru. Helicobacter pylori chronically infects stomachs of billions of people worldwide, is implicated in peptic ulcer disease and gastric cancer, and is very diverse genetically. Different multilocus sequence types (MLST) (genotypes) predominate in different human populations. Shimaa village strains such as Shi470 is more closely related to strains from East Asia than other geographic regions, and is postulated to represent the strains of Native Americans before European conquest. To our knowledge, it is the first H. pylori strain completely sequenced that is not from an ethnic Europeans. Its genome sequence should be valuable for analyses of mechanisms of infection, virulence and genome evolution.