Database of Macrolide Resistance Genes in Gram-positive Bacteria from COVID-19 Patients

This study investigates the prevalence and distribution of macrolide resistance genes in Gram-positive bacteria isolated from COVID-19 patients in Santander, Colombia. The widespread use of azithromycin and other macrolides during the COVID-19 pandemic has contributed to increasing antimicrobial resistance in bacterial pathogens. This descriptive study analyzed 112 nasopharyngeal, oropharyngeal, and tracheal aspirate samples stored from hospitalized COVID-19 patients in 2020, from which 48 Gram-positive strains were isolated. Phenotypic resistance testing and endpoint PCR were employed to identify resistance phenotypes and the presence of macrolide resistance genes, including <i>ermA</i>, <i>ermB</i>, <i>ermT</i>, and <i>mef(A/E)</i>. The findings aim to inform public health strategies on antimicrobial resistance in the context of COVID-19.

本研究针对哥伦比亚桑坦德地区新冠患者分离获得的革兰氏阳性菌（Gram-positive bacteria）中的大环内酯类耐药基因（macrolide resistance genes）的流行率与分布特征展开调查。新冠疫情期间，阿奇霉素及其他大环内酯类药物的广泛使用推动了细菌病原菌抗菌耐药性的上升趋势。本描述性研究对2020年该地区新冠住院患者留存的112份鼻咽、口咽及气管抽吸物样本进行分析，最终分离得到48株革兰氏阳性菌菌株。研究采用表型耐药检测与终点PCR（endpoint PCR）技术，分别鉴定样本的耐药表型以及大环内酯类耐药基因的携带情况，涉及的耐药基因包括ermA、ermB、ermT与mef(A/E)。本研究结果可为新冠疫情背景下的抗菌耐药性公共卫生防控策略制定提供参考依据。

搜集汇总

背景与挑战

背景概述

该数据集记录了COVID-19患者中革兰氏阳性菌的大环内酯类耐药基因分布情况，包含48株菌株的表型和基因型耐药数据，旨在为COVID-19背景下的抗生素耐药性公共卫生策略提供依据。