Omic-analysis of long-term particulate matter-induced pulmonary injury. Mus musculus

Particulate matter (PM) is a huge environmental threat of public concern. Oxidative stress and systemic inflammation are the known factors contributing to PM related damage; however, a systematic understanding of the PM-induced deleterious pulmonary effects by multi-omics analysis is lacking. In this study, we performed transcriptomics, proteomics, and metabolomics analysis in a mouse model of 3-month PM exposure to identify molecular changes in the lung tissues