Puumala (PUU) hantavirus strain differences and insertion positions in the hepatitis B virus core antigen influence B-cell immunogenicity and protective potential of core-derived particles.
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The fine specificity of this epitopic region was further mapped to amino acids 31-40. Four out of five bank voles immunized with the epitope (as an internal insert in Hepatitis B virus core antigen) were protected from challenge with Puumala virus (strain Kazan).
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2000-01-01



