Study Implementation.

*Details obtained from a separate publication of East et al[42] including a subgroup with trauma-induced ARDS by McKinley et al (n = 67)[34].PVL = pressure and volume-limitation,*Subgroup of a multicentre RCT comparing protocol directed, pressure and volume-limited ventilation to non-protocol directed ventilation by East et al (n = 200)[42].Gradients reflect the difference between the control and treatment groups (i.e. Control – Treatment).Characteristics of the study populations are presented as pooled mean and standard deviation.¶idal volume in cc.§APACHE III.Significance Levels.†p≤0.001;‡0.001∥0.01≤p≤0.05.