Interhelical distances at different states observed in simulations and in the crystal structures.

* TM1a (R11 to A22), TM1b (L25 to A35), TM6a (G242 to L255), TM6b (F259 to Y268), and TM10 EC half (K398 to V412) Cα atoms were used for the calculations of the center of mass. Results for OFo/OFo* were taken from our previous study (ref 4); results for OFc* were averaged based on runs 1 to 2; for holo-occluded state, equilibrated conformers in runs 6 and 7 were used; for IFo/IFo*, results were averaged based on runs 8 to 17; for apo-occluded state, equilibrated conformers in runs 18 and 19 were taken.Interhelical distances at different states observed in simulations and in the crystal structures.