There is an urgent need to understand the mechanisms by which the mutations confer resistance in order to design new drugs and to identify new drug targets. Previous studies have reported numerous mut

NIAID Data Ecosystem40

Transmitted Extended-spectrum XDR Tuberculosis in Beijing

结核病耐药性

基因组与表观基因组学

Drug-resistance to tuberculosis remains a major public health threat. Here, we report two cases of extended-spectrum XDR (XXDR) tuberculosis, resistant to most first and second-line agents. Correlatio

NIAID Data Ecosystem60

Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT416

结核病耐药性

结构生物学药物发现

Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT416 Descriptor: DIMETHYL SULFOXIDE, N,N-diethyl-2-[(8-fluoro-5-methyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl

Protein Data Bank Japan2023-10-11 更新40

Determinants of second-line injection drugs in M. tuberculosis

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