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T cell dependent immune responses: B cell activation and differentiation Group1 Fo, Group2 GC1, Group3 GC2

ChEBI2011-03-29 更新2026-07-21 收录

B细胞免疫应答

T细胞依赖性免疫

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-28237 数据链接链接失效反馈

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T cell dependent immune responses: B cell activation and differentiation Group1 Fo, Group2 GC1, Group3 GC2

应用场景：

创建时间：

2011-03-29

B细胞免疫应答

基因缺陷模型

Analyze kinetics, cell composition and proliferation of germinal center B cells in wt vs Ung-/- vs Aicda-/- vs Ung-/- Aicda-/- mice after immunization with model antigens.

NIAID Data Ecosystem80

TET enzymes augment AID expression via 5hmC modifications at the Aicda superenhancer [H3K27ac_ChIP-seq]. TET enzymes augment AID expression via 5hmC modifications at the Aicda superenhancer [H3K27ac_ChIP-seq]

5hmC表观遗传

B细胞免疫应答

TET enzymes are dioxygenases that promote DNA demethylation by oxidizing the methyl group of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Here we report a close correspondence between 5hm

NIAID Data Ecosystem50

IL-21 Shapes the B Cell Response in a Context-Dependent Manner [RNA-seq

B细胞免疫应答

细胞信号传导

The cytokine interleukin-21 (IL-21) is a pivotal T cell-derived signal crucial for germinal center (GC) responses, but the precise mechanisms by which IL-21 influences B cell function remain elusive.

NIAID Data Ecosystem20

CD28 deficiency leads to accumulation of germinal-center independent IgM + experienced B cells and to production of protective IgM during experimental malaria

感染免疫学

B细胞免疫应答

Protective immunity to blood-stage malaria is attributed to Plasmodium-specific IgG and effector-memory T helper 1 (Th1) cells. However, mice lacking the costimulatory receptor CD28 (CD28KO) maintain

NIAID Data Ecosystem60

BCR-Seq of Germinal Center B cells from mice infected with LCMV

B细胞免疫应答

病毒感染的适应性免疫研究

To study how acute or chronic viral infection (LCMV-WE or Docile) affect somatic hypermutation and/or affinity maturation of Germinal Center B cells, wild-type or Bmi1-deleted mice were infected with

NIAID Data Ecosystem30

T cell dependent immune responses: B cell activation and differentiation Group1 Fo, Group2 GC1, Group3 GC2

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