Spreadsheet of de-identified raw data.

BackgroundLatino populations remain vastly underrepresented in clinical and translational research. This study aims to characterize the most common sources of successful participant engagement within our sample.MethodsBetween February 2022 and March 2023, research staff systematically recorded how participants learned about an ongoing study (which we term source of successful participant engagement) designed to co-create and implement a COVID-19 testing program in a U.S./Mexico border community. Demographic characteristics were correlated with each source of participant engagement at the univariate level using a chi-squared test and, if significant, were included in a multinomial logistic regression model to determine the association between participant characteristics and source of participant engagement.ResultsA total of 2836 individuals responded to questions regarding source of participant engagement; the most common responses were: Word of Mouth (32%), Clinic/Provider referral (32%), and Walk Up to the testing site (21%). Males were 35% less likely than female participants to report having heard of the study through their Clinic/Provider compared to Walk Up (p 54 years of age to have learned about the study through Word of Mouth compared to Walk Up (p ConclusionAdvancing our understanding of sources of successful participant engagement in marginalized communities is necessary to increase equitable participation in clinical and translational research.