Parameter estimated for development and differentiation of HAE systems for different conditions: Parameters were estimated by fitting the model for epithelial differentiation dynamics (Eqs (1)–(2), Fig 1B) to data from ALI-cultures of nasal epithelium [36] and of bronchial epithelial tissue exposed to 2.5% and 5% cigarette smoke extract (CSE)[21].
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Values indicate best estimate and 90%-credible intervals (CrI) of estimates using an Approximate Bayesian Computation approach (pyABC, [23]) running for 15 generations with 2000 particles each.
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2023-08-11
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