DataSheet_1_Prognostic and clinicopathological role of pretreatment systemic immune-inflammation index in patients with oral squamous cell carcinoma: a meta-analysis.docx

BackgroundThere are many studies regarding the use of systemic immune-inflammation index (SII) to help predict oral squamous cell carcinoma (OSCC) prognosis, but findings have been inconsistent. The present meta-analysis was conducted to determine whether SII could contribute to predicting OSCC prognosis.MethodsPubMed, Embase, Cochrane Library and Web of Science databases were thoroughly searched from their inceptions through August 20, 2023. The role of SII in predicting OSCC prognosis was determined through combined hazard ratios (HRs) with relevant 95% confidence intervals (CIs). Correlations of SII with clinicopathological characteristics of OSCC patients were analyzed based on combined odds ratios (ORs) with 95% CIs.ResultsThis meta-analysis utilized 11 articles in total, involving 3,464 patients. According to the results, an elevated SII was markedly associated with dismal overall survival (OS) (HR=1.85, 95%CI=1.48-2.29, p

背景：众多研究致力于探讨系统性免疫炎症指数（SII）在预测口腔鳞状细胞癌（OSCC）预后方面的应用，然而研究结果尚不一致。本研究通过荟萃分析旨在确定SII是否能够对OSCC预后预测有所贡献。方法：对PubMed、Embase、Cochrane Library和Web of Science数据库自创立至2023年8月20日的文献进行了全面检索。通过综合相对风险比（HRs）及其相应的95%置信区间（CI），确定了SII在预测OSCC预后中的作用。基于综合比值比（ORs）及其95%置信区间，分析了SII与OSCC患者临床病理特征的相关性。结果：本次荟萃分析共纳入11篇文章，涉及3,464名患者。结果显示，升高的SII与较差的总生存期（OS）显著相关（HR=1.85，95%CI=1.48-2.29，p值未给出）。